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KMID : 0812020080140020115
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Korean Journal of Neurogastroenterology and Motility
2008 Volume.14 No. 2 p.115 ~ p.121
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Therapeutic Effects of Agio(R) 18 g per Day in Patients with Constipation Dominant Irritable Bowel Syndrome and Chronic Constipation
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Eum Jun-Bum
Rhee Kyoung-Hoon
Cho Yoon-Kyung
Byeon Jeong-Sik
Myung Seung-Jae
Jung Hwoon-Yong
Kim Jin-Ho
Kim Soo-Jeung
Kim Ji-Eun
Sohn Hee Jung
Rhee Poong-Lyul
Rhee Jong-Chul
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Abstract
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Background/Aims: Agio® is one of the bulk-forming laxatives, composed of Plantago seed and Ispaghula husk. This study was designed to evaluate the effects and safety of Agio® 18 g per day in patients with chronic constipation.
Methods: We enrolled 24 patients with constipation-dominant irritable bowel syndrome and chronic constipation diagnosed by Rome Ⅱ criteria. Agio® 18 g per day was administered to these patients for 21 days. We compared the symptoms related to constipation before and after Agio® administration. We also compared colon transit time before and after Agio® administration. Adverse events related to Agio® administration were investigated.
Results: Symptom changes before and after Agio® administration were as follows: 1) frequency of bowel movement (2.3 vs. 1.7, p<0.05), 2) straining during defecation (6.9 vs. 4.6, p<0.001), 3) stool forms and consistency by Bristol stool scale (2.1 vs. 3.0, p<0.05), 4) sensation of incomplete evacuation (5.9 vs. 4.3, p<0.001), 5) sensation of anorectal obstruction or blockage (7.1 vs. 4.7, p<0.05), 6) abdominal discomfort (6.5 vs. 4.8, p<0.001) and 7) satisfaction of defecation (2.3 vs. 4.1, p<0.05). Total colon transit time was 46.4±18.3 hours before Agio® administration while 37.9±16.7 hours after Agio® administration (p=0.020). No significant adverse events related to Agio® administration occurred.
Conclusions: Agio® 18 g per day for 21 days seems to be effective and safe in patients with constipation-predominant irritable bowel syndrome and chronic onstipation.
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KEYWORD
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Agio, Constipation, Colon transit time
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